Emergence and spread of antibiotic resistance following exposure to antibiotics
نویسندگان
چکیده
منابع مشابه
Emergence and spread of antibiotic resistance: setting a parameter space
The emergence and spread of antibiotic resistance among human pathogens is a relevant problem for human health and one of the few evolution processes amenable to experimental studies. In the present review, we discuss some basic aspects of antibiotic resistance, including mechanisms of resistance, origin of resistance genes, and bottlenecks that modulate the acquisition and spread of antibiotic...
متن کاملAntibiotics and Antibiotic Resistance
A AAC(60)-Ib-cr, 185 ACHN-975 clinical studies, 163–164 medicinal chemistry, 166 structure, 162 AcrAB-TolC, 180 AcrD, 236 AdeRS, 257 AFN-1252 mechanism of action, 148, 153 resistance, 153 structure, 149 AIM-1, 74 Amicoumacin A, 222 Amikacin indications, 240 structure, 230 synthesis, 4 Aminoglycosides. See also specific drugs historical perspective, 229–230 indications, 239–241 mechanism of acti...
متن کاملOrigin and Evolution of Antibiotic Resistance: The Common Mechanisms of Emergence and Spread in Water Bodies
The environment, and especially freshwater, constitutes a reactor where the evolution and the rise of new resistances occur. In water bodies such as waste water effluents, lakes, and rivers or streams, bacteria from different sources, e.g., urban, industrial, and agricultural waste, probably selected by intensive antibiotic usage, are collected and mixed with environmental species. This may cau...
متن کاملImpact of Rapid Susceptibility Testing and Antibiotic Selection Strategy on the Emergence and Spread of Antibiotic Resistance in Gonorrhea
Background Increasing antibiotic resistance limits treatment options for gonorrhea. We examined the impact of a hypothetical point-of-care (POC) test reporting antibiotic susceptibility profiles on slowing resistance spread. Methods A mathematical model describing gonorrhea transmission incorporated resistance emergence probabilities and fitness costs associated with resistance based on chara...
متن کاملAntibiotic Resistance: Origins, Evolution, Selection and Spread
Antibiotic resistance thwarts the treatment of infectious diseases worldwide. Although a number of factors can be identified which contribute to the problem, clearly the antibiotic as a selective agent and the resistance gene as the vehicle of resistance are the two most important, making up a 'drug resistance equation'. Both are needed in order for a clinical problem to arise. Given sufficient...
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ژورنال
عنوان ژورنال: FEMS Microbiology Reviews
سال: 2011
ISSN: 1574-6976
DOI: 10.1111/j.1574-6976.2011.00295.x